The use of, and outcomes associated with, systemic treatments in patients with cancer in routine care in England. Analyses of outcomes using the SACT dataset. Short title: Systemic treatments in malignancy

Data-sharing agreement from NHS England Data Uses Register. Evidence status: source reported.

Organisation: UNIVERSITY OF OXFORD
Published: 2026-10-23
Source reference: DARS-NIC-656855-D5T2Z-v1.3
Jurisdiction: England
Licence: Open Government Licence v3.0, subject to NHS England terms and exclusions

The Data will be used for the purpose of a research project: The use of, and outcomes associated with, systemic treatments in patients with cancer in routine care in England. Analyses of outcomes using the SACT dataset. Short title: Systemic treatments in malignancy. The Data will be used to answer the following questions: Primary objective: study survival outcomes in large well-defined cohorts of patients receiving cancer drugs with a clearly defined place in therapy for poor prognosis cancer Secondary Objectives: - To define patient, system and organisational characteristics that may influe…

Register reference: DARS-NIC-656855-D5T2Z-v1.3
Applicant type: Academic
Data controllers: UNIVERSITY OF OXFORD
Agreement period: 2026-10-23 to 2029-10-31
For commercial purposes (as marked in the register): No
Release files listed by NHS England: 0

Data approved

NDRS Cancer Registrations
NDRS Linked Cancer Waiting Times (Treatments only)
NDRS Linked DIDs
NDRS Linked HES AE
NDRS Linked HES APC
NDRS Linked HES Outpatient
NDRS National Cancer Patient Experience Survey (CPES)
NDRS National Radiotherapy Dataset (RTDS)
NDRS Somatic Molecular Dataset
NDRS Systemic Anti-Cancer Therapy Dataset (SACT)

Objective, as published

Expected benefits, as published

To provide a perspective on outcomes from the use of cancer drugs within the context of routine care. These include survival outcomes and serious toxicities. This will better inform patients and clinicians and inform health economic analyses. This has previously largely been done using outcomes from prospective trials but these have limited external generalisability and may not reflect outcomes in routine care.

Benefits reported by the applicant

The SACT data have enabled the University of Oxford to examine the delivery, safety and outcomes of systemic anti-cancer treatment at population level in routine NHS practice. This provides information that cannot readily be obtained from clinical trials alone, particularly for patient groups who are often under-represented in trials, including older people and patients with substantial comorbidity. The work has generated evidence on patterns of treatment, treatment-associated outcomes, and variation between patient groups and other characteristics across a number of cancers. In particular, analyses using these data have helped to: • describe how systemic anti-cancer treatments are used in routine NHS practice and how treatment patterns and outcomes differ • quantify outcomes in older and…

This is the applicant's own account; OpenHDI has not verified it.

Source: https://digital.nhs.uk/services/data-access-request-service-dars/data-uses-register. Captured 2026-11-05.

Limitations: Data-sharing agreement as published in NHS England's Data Uses Register. An agreement permits access; actual data releases are listed separately. Expected and yielded benefits are as reported by the applicant and have not been independently verified. Long text fields can be cut off in NHS England's spreadsheet export at Excel's 32,767-character cell limit.