Long-term outcomes in women diagnosed with non-invasive breast cancer (ODR1516_255)

Data-sharing agreement from NHS England Data Uses Register. Evidence status: source reported.

Organisation: UNIVERSITY OF OXFORD
Published: 2026-10-15
Source reference: DARS-NIC-656763-K3F9R-v2.5
Jurisdiction: England
Licence: Open Government Licence v3.0, subject to NHS England terms and exclusions

The Data will be used for the purpose of a research project: Long-term outcomes in women diagnosed with non-invasive breast cancer (ODR1516_255)] The Data will be used to answer the following objectives: Primary objective: • Characterise the risk of developing invasive breast cancer among women diagnosed with a non-invasive breast cancer, and the factors that determine this risk. Secondary objectives: • Characterise the risk of death from breast cancer in women diagnosed with a non-invasive breast cancer, and the factors that determine this risk. • Characterise the risk of develo…

Register reference: DARS-NIC-656763-K3F9R-v2.5
Applicant type: Academic
Data controllers: UNIVERSITY OF OXFORD
Agreement period: 2026-10-15 to 2028-12-31
For commercial purposes (as marked in the register): No
Release files listed by NHS England: 0

Data approved

NDRS Cancer registration (pre-1995)
NDRS Cancer Registrations
NDRS Linked Cancer Waiting Times (Treatments only)
NDRS Linked HES APC
NDRS National Radiotherapy Dataset (RTDS)
NDRS Systemic Anti-Cancer Therapy Dataset (SACT)

Objective, as published

Expected benefits, as published

The research is hoped to advance clinical understanding of DCIS, help shape national screening and treatment guidelines, improve patient care pathways, and demonstrated the value of population‑level data in informing both policy and practice. This study is expected to provide policymakers with the information needed to inform the optimal surveillance and management of DCIS. It is expected to have implications for the frequency and duration of screening mammography for women diagnosed with DCIS. The findings of this research study are expected to contribute to evidence‑based decision‑making for policy‑makers, clinicians, and patients, informing best practice to improve the care, treatment, and experience of health care users relevant to the subject matter of the study. The use of the data…

Benefits reported by the applicant

Two papers arising from this work have been published in the British Medical Journal (BMJ, Impact Factor 96). The measurable benefits to health and social care yielded to date are outlined below: (1) Mannu GS, Wang Z, Dodwell D, Broggio J, Charman J, Darby SC. Invasive breast cancer and breast cancer death after non-screen detected ductal carcinoma in situ from 1990 to 2018 in England: population-based cohort study. BMJ. 2024; 27;369. (PMID: 38267073) Impact: Prior to this study, the long-term outcomes following pre-invasive breast cancer, specifically ductal carcinoma in situ (DCIS), were unknown. This paper presented a population-based observational cohort study describing the long-term outcomes for all women diagnosed with DCIS outside the NHS breast screening programme in England. For…

This is the applicant's own account; OpenHDI has not verified it.

Source: https://digital.nhs.uk/services/data-access-request-service-dars/data-uses-register. Captured 2026-11-05.

Limitations: Data-sharing agreement as published in NHS England's Data Uses Register. An agreement permits access; actual data releases are listed separately. Expected and yielded benefits are as reported by the applicant and have not been independently verified. Long text fields can be cut off in NHS England's spreadsheet export at Excel's 32,767-character cell limit.