GUY'S AND ST THOMAS' NHS FOUNDATION TRUST: Infective endocarditis (IE) is a life-threatening condition caused by infection within the heart, most commonly on a heart valve.

Data-sharing agreement from NHS Digital registers of approved data releases, 2014–2019. Evidence status: source reported.

Organisation: GUY'S AND ST THOMAS' NHS FOUNDATION TRUST
Source reference: DARS-NIC-91878-Y4M2P-v0.14
Jurisdiction: England
Licence: Open Government Licence v3.0, subject to NHS England terms and exclusions

Register reference: DARS-NIC-91878-Y4M2P-v0.14
Agreement period: not published to no end date published
For commercial purposes (as marked in the register): Not stated
Release files listed by NHS England: 29

Data approved

Hospital Episode Statistics Admitted Patient Care

Objective, as published

Infective endocarditis (IE) is a life-threatening condition caused by infection within the heart, most commonly on a heart valve. IE is much more common in people who have undergone a heart valve replacement. Since 2007 a new keyhole method of heart valve replacement – transcatheter valve implantation (TVI) – has been available, which avoids the need for open heart surgery. TVI is mainly used for patients who are too frail to undergo open heart surgery. There are very few studies examining the risk of IE after valve replacement by TVI. Guys & St Thomas NHS Foundation Trust want to understand how many patients develop this complication, which patients are affected, and to look at how many patients ultimately survive. Guys & St Thomas NHS Foundation Trust also plan to compare the risk of IE after TVI with the risk of IE after conventional open heart surgery. Finally, Guys & St Thomas NHS Foundation Trust will look at whether the number of heart valve replacement patients who develop IE has changed over time. Specifically, the study will look at the numbers of patients with IE before and after 2008, when UK guidelines from NICE advised stopping antibiotics prescriptions for prevention of IE. The study design is a retrospective cohort analysis. Patients who have undergone TVI will be identified from datasets held by the National Institute for Cardiovascular Outcomes Research (NICOR) - the UK TAVI registry (for transcatheter aortic valve intervention), the National Congenital Hea…

Expected benefits, as published

Outputs will benefit future patients receiving prosthetic valves, in addition to cardiologists and microbiologists managing the care of patients with infective endocarditis. Two major benefits are anticipated: a) This study will help ascertain whether there has been a rise in cases of infective endocarditis (IE) in patients who have undergone prosthetic valve replacement since UK guidelines were changed (to restrict use of antibiotic prophylaxis) in 2008. This will provide surrogate evidence on the efficacy of antibiotic prophylaxis, and in turn, information on whether the UK currently has the correct policy on use of antibiotic prophylaxis. b) Insight into risk factors and outcome for patients who develop infective endocarditis after transcatheter valve replacement. This is a rapidly gro…

Source: https://webarchive.nationalarchives.gov.uk/ukgwa/2019/https://digital.nhs.uk/binaries/content/assets/legacy/excel/2/1/releaseregister20171201_20180228.xlsx. Captured 2026-10-30.

Limitations: Agreement as recorded in an NHS Digital register of approved data releases (2014–2019), retrieved from the UK Government Web Archive. That register lists releases made in its period and the agreement's purpose statement as it then stood; it gives no agreement dates, and the agreement may have changed since. Imported only where a paper quotes a reference no current register holds.