HULL AND EAST YORKSHIRE HOSPITALS NHS TRUST: Obesity, through insulin resistance, is a potent risk factor for Type 2 diabetes mellitus (T2DM).

Data-sharing agreement from NHS Digital registers of approved data releases, 2014–2019. Evidence status: source reported.

Organisation: HULL AND EAST YORKSHIRE HOSPITALS NHS TRUST
Source reference: DARS-NIC-392244-H3M3G-v0.0
Jurisdiction: England
Licence: Open Government Licence v3.0, subject to NHS England terms and exclusions

Register reference: DARS-NIC-392244-H3M3G-v0.0
Agreement period: not published to no end date published
For commercial purposes (as marked in the register): Not stated
Release files listed by NHS England: 3

Data approved

MRIS - Flagging Current Status Report
MRIS - Cause of Death Report

Objective, as published

Obesity, through insulin resistance, is a potent risk factor for Type 2 diabetes mellitus (T2DM). Obesity accounts for 80% of the overall risk of developing T2DM and appears to be the main cause of its increasing worldwide prevalence. In the UK, obesity is predicted to affect 60 per cent of adult men and 50 per cent of adult women by 2050 and, if this is true, then the prevalence of T2DM will also increase. The association between obesity and the increased risk of cardiovascular disease (CVD) is well established in the general population. However, once CVD is established, obesity seems to confer a paradoxical benefit. There is growing evidence that overweight patients with CVD survive longer than their normal-weight counterparts; an effect called the “obesity paradox”. Although obesity has been shown to account for much of the risk of developing T2DM, a similar obesity paradox may exist in this condition too. However, results are more conflicting for diabetic patients, with studies alternating between positive and negative associations between CVD, mortality and Body Mass Index (BMI), or other weight indexes. Biased populations, inadequate study power and incomplete adjustment for comorbidities may be some of the reasons behind this inconsistency among the reported studies to date. The aim of this study is to assess the relationship of obesity, CVD and mortality in Diabetes Mellitus, by addressing some of the issues that might have accounted for the inconsistent results in o…

Expected benefits, as published

The study aims to provide more evidence on the relationship between body weight, morbidity and mortality in Diabetes Mellitus in order to improve understanding and treatment of the risks associated. There is a perception that patients with diabetes and normal weight are healthier than overweight patients with diabetes but this has shown that the reverse may be true. Understanding this is key to providing appropriate treatment. This research could make a difference to the care of millions of people with diabetes and ensure better use of NHS and research spend and resources. The medical fraternity and many members of the public will benefit from the dissemination of the study findings and these will inform research that leads to better care. Several eminent clinical scientists have asked wh…

Source: https://webarchive.nationalarchives.gov.uk/ukgwa/2019/http://content.digital.nhs.uk/media/23861/Release-Register-December-16---February-17/xls/Release_Register__December_16_-_February_17.xlsx. Captured 2026-10-30.

Limitations: Agreement as recorded in an NHS Digital register of approved data releases (2014–2019), retrieved from the UK Government Web Archive. That register lists releases made in its period and the agreement's purpose statement as it then stood; it gives no agreement dates, and the agreement may have changed since. Imported only where a paper quotes a reference no current register holds.