GUY'S AND ST THOMAS' NHS FOUNDATION TRUST: To establish the relapse rate of infective endocarditis within one year, in patients treated with heart valve surgery at the Guys & St Thomas Trust (GSTT) centre over a 10 year per

Data-sharing agreement from NHS Digital registers of approved data releases, 2014–2019. Evidence status: source reported.

Organisation: GUY'S AND ST THOMAS' NHS FOUNDATION TRUST
Source reference: DARS-NIC-35216-D6G6M-v0.9
Jurisdiction: England
Licence: Open Government Licence v3.0, subject to NHS England terms and exclusions

Register reference: DARS-NIC-35216-D6G6M-v0.9
Agreement period: not published to no end date published
For commercial purposes (as marked in the register): Not stated
Release files listed by NHS England: 11

Data approved

Hospital Episode Statistics Admitted Patient Care

Objective, as published

To establish the relapse rate of infective endocarditis within one year, in patients treated with heart valve surgery at the Guys & St Thomas Trust (GSTT) centre over a 10 year period. Infective endocarditis (IE) is a deadly disease associated with high mortality (15 - 30%) and severe complications. It is caused by transient bacteria in the bloodstream attaching on to the endocardium and heart valves leading to destruction of the valve tissue with often fatal consequences. Emergency treatment is required in a specialist centre with intensive and prolonged intravenous antibiotic therapy and often high risk cardiac valve surgery. This is a costly and protracted treatment regime including intensive care and frequent outpatient follow ups. Added to this is the ever increasing concern regarding antimicrobial resistance and antibiotic side effects. Should the patient survive the initial episode and treatment, there remains an elevated risk of relapse. However, because the incidence is low and the early mortality rate high, there is limited evidence to improve the management and randomised trials are almost impossible to conduct. Therefore retrospective studies (such as this audit) can provide valuable new information for meta-analysis. As GSTT are a specialist centre, there is a cohort of patients treated for IE that can provide valuable evidence to improve management of IE. The objective for this project is to evaluate whether the antibiotic regime (which is shorter and therefore…

Expected benefits, as published

The final report will be fed back to GSTT clinicians and implemented into clinical practice. If the findings show a low relapse rate after abbreviated antibiotic treatment courses, GSTT anticipate these findings will influence UK practice and national/international guidelines. The results will be published in a peer-reviewed journal and will thus be available to reviewers planning future national or international guidance documents. The consequences of a shorter-than-recommended courses of antibiotics are reduced costs, less generation of antimicrobial resistance, and less antibiotic side effects. The patient benefit will be improved survival combined with a shorter hospital stay and fewer hospital clinic follow ups. A target date is difficult to define in this situation but current pract…

Source: https://webarchive.nationalarchives.gov.uk/ukgwa/2019/http://content.digital.nhs.uk/media/23167/Data-Release-Register-September---November-2016/xls/Data_Release_Register__September_-_November_2016.xlsx. Captured 2026-10-30.

Limitations: Agreement as recorded in an NHS Digital register of approved data releases (2014–2019), retrieved from the UK Government Web Archive. That register lists releases made in its period and the agreement's purpose statement as it then stood; it gives no agreement dates, and the agreement may have changed since. Imported only where a paper quotes a reference no current register holds.