University of Oxford: A randomised controlled trial of iodine supplementation in preterm infants (I2S2) Primary research question: Does iodide supplementation of extreme preterm infants change neurodeve

Data-sharing agreement from NHS Digital registers of approved data releases, 2014–2019. Evidence status: source reported.

Organisation: University of Oxford
Source reference: DARS-NIC-148436-W4NL6-v0.0
Jurisdiction: England
Licence: Open Government Licence v3.0, subject to NHS England terms and exclusions

Register reference: DARS-NIC-148436-W4NL6-v0.0
Agreement period: not published to no end date published
For commercial purposes (as marked in the register): Not stated
Release files listed by NHS England: 4

Data approved

MRIS - Cause of Death Report
MRIS - Cohort Event Notification Report
MRIS - Scottish NHS / Registration

Objective, as published

A randomised controlled trial of iodine supplementation in preterm infants (I2S2) Primary research question: Does iodide supplementation of extreme preterm infants change neurodevelopmental outcome at 2 years corrected age? Secondary research question: What is the relationship between supplementation, blood levels of thyroid hormones, illness, drug usage, other events of postnatal period and neurodevelopment? Specifically includes -Collection of blood levels of T4, TSH and TBG on day 7, 14, 28 and 34 weeks corrected age will confirm the efficacy of iodide supplementation; and will distinguish between transient hypothyroxinaemia, transient hypothyroidism and transient hyperthyrotropinaemia. If this work shows benefit to the supplemented neonates there will be worldwide clinical support for iodide supplementation for preterm infants. The study hopes to achieve iodide sufficiency in parentally fed infants, ensuring that the nutrition is adequate for development. In addition, the current iodide recommendation of 1mcg/kg/day extends to term infants and children up to 15 kg and they are also likely to benefit.

Source: https://webarchive.nationalarchives.gov.uk/ukgwa/2019/http://content.digital.nhs.uk/media/23861/Release-Register-December-16---February-17/xls/Release_Register__December_16_-_February_17.xlsx. Captured 2026-10-30.

Limitations: Agreement as recorded in an NHS Digital register of approved data releases (2014–2019), retrieved from the UK Government Web Archive. That register lists releases made in its period and the agreement's purpose statement as it then stood; it gives no agreement dates, and the agreement may have changed since. Imported only where a paper quotes a reference no current register holds.